megatomi.com Secrets
megatomi.com Secrets
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Our new Distinct+ tissue clearing technique is the only real strategy that delipidates samples without any alter in morphology and with negligible influence on structural integrity.
Megatome is a vibrating microtome designed to segment a wide choice of samples, from organoids and biopsy samples to expanded rodent brains and intact human organs. With substantial blade vibrating frequency and minimized blade deflection, Megatome enables superior-throughput tissue sectioning with uniform floor profile, along with minimal tissue harm and data loss.
Antibodies may choose weeks to diffuse by just a few millimeters of tissue, by using a steep labeling gradient from surface to Main.
Megatome is suitable for accuracy: the blade vibrates at a greater frequency and bigger amplitude variety than other microtomes, and encompasses a distinctive deflection Regulate system.
SE makes use of a rotational electrical discipline to disperse hugely electromobile molecules (for example antibodies or surfactant micelles) in the course of a porous sample without the need of harmful electrically charged constructions inside the tissue. This permits two-4 working day clearing of intact organs,
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Megatome can be a novel microtome that permits for high-precision sectioning of a variety of tissue samples – from organoids, to arrays of animal organs, to intact human Mind hemispheres – with negligible tissue destruction and knowledge reduction.
It’s the perfect time to up grade your microtome to Megatome. With correct higher-frequency slicing for an unmatched number of sample dimensions and kinds – from organoids and tumors to expanded tissues, sample arrays, and intact primate organs – Megatome is optimized for various applications.
Thoroughly delipidate entire mouse brains or comparably sized samples in only one working day with SmartBatch+, or in one 7 days with our passive clearing kit.
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Defend avoids the variability of hydrogel embedding and the data loss from PFA preservation, defending specimens for many rounds of processing.
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Our novel Protect tissue preservation technique forms intramolecular bonds making use of polyfunctional, versatile epoxides to stabilize tissue architecture and safeguard the sample’s endogenous fluorescence, protein antigenicity and nucleic acids.